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A review of existing studies on the effect of CBD found that CBD use in animals resulted in several serious issues, including: Developmental toxicity Embryo-foetal mortality Central nervous system inhibition These involved doses that were larger than the recommended amount for human consumption, however

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Although smoking prevalence in the Philippines has decreased from nearly 30% in 2009, the economic burden of tobacco use continues to be significant, costing an estimated Php 261 billion (US $4.6 billion) per year

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